Abstract: Fluorapatite was prepared by adopting double decomposition method, and the properties were characterized by XRD, XPS and antibiotic testing. The structure and antibacterial effect of zinc ion doped and no zinc ion doped fluorapatite were compared. The results indicate that the factors of sintering temperature, doping metal ions and drying method have obvious effect on the antibiotic property of the materials, and the silver-zinc ion doped antibiotic material, sintered at 1000℃ and dried at low temperature shows the best antibacterial property.