Abstract: In this paper,a simple and low-cost method for improving the performance of the neural microelectrodes is reported.Firstly,a photosensitive polyimide（Durimide 7510） was chosen as substrate to fabricate implantable flexible microelectrodes instead of silicon-based neural microelectrodes.Then,an electrochemical polymerization of conducting polymer PEDOT/LiClO₄ was performed to modify the surface of the microelectrode sites.The morphology,electrical properties and biocompatibility of the coated microelectrodes were also investigated.The results showed that,due to the rough and cauliflower-like surface of the modified microelectrode sites which provides a higher interfacial area,the impedance of the microelectrode decreased to the original 1/20（@ 1KHz） and the charge injection capacity increased by about 100-fold.Biological tests also demonstrated that the modification of the microelectrode improved the interfacial properties for cell attachment and proliferation.Cell adhesion rate was 92.5% higher than that on unmodified surface;and survival rate also increased from 69.2% to 85.4%.Furthermore,the flexible polyimide substrate also exhibited good biocompatibility.