Abstract: Nitric oxide（NO） is an important biological messenger molecules and effect molecules in vivo,which plays an important role in physiology and disease process.It’s of great significance to achieve for rapid and accurate detection of NO in the biological body.And the fiber-optic NO sensor is one of the most promising detection methods now.In this paper,we reviewed the current research of fiber-optic NO sensor at home and abroad,introduced several new NO probes and detection methods that can be used in fiber-optic sensor in detail,and discussed the existing problems and development trends of the NO fiber-optic sensing technology.