Abstract: This paper aims to study modified electrodes with the advantages of both self-assembled monolayers and the graphene,to develop electrochemical interface signals detection system. At the same time,it aims to analyse the construction of graphene based field effect transistors （GFETs） modified by SAMs. Research conducted has shown that graphene functionalized with SAMs can provide a useful way of controlling its properties by reducing interfacial effects between graphene and neighbouring materials.This paper also discusses the applications on dye-sensitized solar cell and p-n junctions using graphene modified by self-assembled monolayers.