Abstract: The two-dimensional transition metal carbon/nitrogen compound named MXene is a new kind of two-dimensional layered nanomaterial, whose general equation is M_n+1X_n (n=1-3). Because of its ultrathin structure and unique physicochemical (mechanical, electronic, electrochemical, etc.) properties, MXene is an ideal electrochemical interface material in the field of bioelectronics. This paper reviews the research progress of MXene in the field of bioelectronics, with emphasis on the preparation, modification and structure-activity relationship of MXene composites. The applications of mechanical sensors, electrochemical sensors, and electrophysiological signal sensors corresponding to their functional characteristics are described. Finally, the future research direction of the bioelectronic materials based on MXene is prospected.