Abstract: Direct electrolysis of seawater for hydrogen production has broad application prospects, but the slow kinetics of the oxygen evolution reaction (OER) and the side reaction of chlorine evolution severely limit the large-scale application of this technology.Therefore, developing efficient OER catalysts to enhance the OER rate and avoid chlorine evolution reaction has become a research focus.Nickel-ironbased catalysts are highly regarded for their high oxygen evolution catalytic activity and low cost.This article reviews the nickel-iron-based OER catalysts, electrode reaction mechanisms, and the latest developments of these catalysts in electrolysis of seawater for hydrogen production.It also discusses the future direction of NiFe-based catalysts, providing a reference for the development of OER electrodes in seawater electrolysis for hydrogen production.