Abstract: Traditional materials research relaying on trial and error has increasingly become the bottleneck for the development and breakthroughs of modern materials industry. Innovative materials genome technology has become a hotspot in materials science research due to it can shorten the cycle of new materials development and reduce research costs. This paper mainly introduces three parts of materials genome technology: high-throughput calculation, high-throughput experimentation, material database. Some representative works are also mentioned. Then the materials genome researches in the field of integrated circuits (IC) are reviewed. In addition, the complexity and optimize ability of the IC materials genome research are pointed out, and we recommend accelerating the innovation and development of integrated circuit materials by using materials genome technology.